5 years ago
CRISPR Just Got More Powerful With an "On” Switch
For all its gene-editing prowess, mechanistically CRISPR is a bit like a power tool with a broken “off” switch. Hear me out: the entire CRISPR machinery is designed in a test tube, and once constructed it’s always on. When introduced into animals or humans, CRISPR is set to roam the entire body, seeking its target gene to edit or destroy until it loses steam and gets metabolized by the body.
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