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+4 +1
CRISPR Approach To Fighting Cancer Called 'Promising' In 1st Safety Test
Attempts to use the gene-editing tool CRISPR to develop a treatment for cancer seem safe and feasible in the earliest findings from the first three patients. "So far, so good," scientists say.
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+16 +1
New CRISPR Class Expands Genetic Engineering Toolbox
Biomedical engineers at Duke University have used a previously unexplored CRISPR technology to accurately regulate and edit genomes in human cells.
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+2 +1
CRISPR flies have been gene edited so they can eat poison
Scientists at the University of California, Berkeley have used the CRISPR gene-editing tool to give fruit flies an evolutionary advantage they’ve never had before. By making just three small changes to a single gene, the team gave the flies the ability to effectively eat poison and store it in their bodies, protecting themselves from predators in the process.
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+14 +1
Researchers unlock potential to use CRISPR to alter the microbiome
Researchers at Western University have developed a new way to deliver the DNA-editing tool CRISPR-Cas9 into microorganisms in the lab, providing a way to efficiently launch a targeted attack on...
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+25 +1
Geneticists retract study suggesting first CRISPR babies might die early
A study that raised questions over the future health of the world’s first gene-edited babies has been retracted because of key errors that undermined its conclusion.
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+19 +1
CRISPR therapy may reverse autism mutation’s effects well past infancy
Injecting the gene-editing tool CRISPR into the brains of adolescent mice counteracts the effects of a mutation in a top autism gene. The finding suggests that mutations in this gene, SCN2A, may be treatable at any age.
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+18 +1
A New Crispr Technique Could Fix Almost All Genetic Diseases
Andrew Anzalone was restless. It was late fall of 2017. The year was winding down, and so was his MD/PhD program at Columbia. Trying to figure out what was next in his life, he’d taken to long walks in the leaf-strewn West Village. One night as he paced up Hudson Street, his stomach filled with La Colombe coffee and his mind with Crispr gene editing papers, an idea began to bubble through the caffeine brume inside his brain.
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+16 +1
CRISPR used to edit rice DNA as defense against pathogen
Altering rice genes the pathogen needs renders rice strains resistant to blight.
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+20 +1
CRISPR kills HIV and eats Zika 'like Pac-man'. Its next target? Cancer
HIV has no cure. It’s not quite the implacable scourge it was throughout the 1980s and 1990s, thanks to education, prophylactics, and drugs like PrEP. But still, no cure.The same ability, though, could be HIV’s undoing. All because of CRISPR. You know, CRIPSR: the gene-editing technique that got everyone really excited, then really sceptical, and now cautiously optimistic about curing a bunch of intractable diseases.
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+15 +1
It’s Happening: US Scientists Reportedly Made a Genetically Modified Human Embryo
What now? Researchers in Portland, Oregon have used a powerful gene editing tool called CRISPR to create genetically modified human embryos, MIT Technology Review reported on Wednesday in an exclusive. This is the first confirmed case of the gene editing of human embryos in the US, and gets scientists closer to the ability to create genetically engineered humans.
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+18 +1
CRISPR used to peer into human embryos' first days
Gene-edited human embryos have offered a glimpse into the earliest stages of development, while hinting at the role of a pivotal protein that guides embryo growth. The first-of-its-kind study stands in contrast to previous research that attempted to fix disease-causing mutations in human embryos, in the hope of eventually preventing genetic disorders. Whereas those studies raised concerns over potential ‘designer babies’, the latest paper describes basic research that aims to understand human embryo development and causes of miscarriage.
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+30 +1
Why CRISPR-Edited Food May Be in Supermarkets Sooner Than You Think
In September, the U.S. Department of Agriculture gave the green light to a version of the plant Camelina sativa, an important oilseed crop that had been genetically engineered using CRISPR to produce enhanced omega-3 oil. What was interesting about this approval was that the USDA did not ask that the inventors of the plant endure the usual regulatory hoops required to sell biotech crops. The next month, a drought-tolerant soybean variety developed with CRISPR also got a quick pass from the USDA.
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+17 +1
New gene therapy could cure a deadly disease that stops the heart from beating
Scientists have successfully tweaked the DNA in human heart cells to correct mutations that cause a deadly disease. If the gene-editing technique is proven safe, it could permanently cure children with a genetic disorder that leaves them wheelchair-bound by their early teens. The genetic disease targeted in this study is called Duchenne muscular dystrophy (DMD), a disorder that affects about one in 5,000 males and causes the progressive wasting away of skeletal and heart muscles.
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+18 +1
CRISPR/Cas9 -mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infection
Author summary The causative agent of malaria, Plasmodium, has to complete a complex infection cycle in the Anopheles gambiae mosquito vector in order to reach the salivary gland from where it can be transmitted to a human host. The parasite’s development in the mosquito relies on numerous host factors (agonists), and their inhibition or inactivation can thereby result in suppression of infection and consequently malaria transmission.
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+17 +1
I Have A Rare Genetic Disease. CRISPR Might Fix It.
Right before I turned five, I went to the eye doctor for the first time. I even wrote about it in my kindergarten journal: “I am going to get galassis! I am so aixidad!” (I was a complicated speller.) At that appointment, I was diagnosed with vitelliform macular dystrophy, a degenerative eye disease also known as “Best disease.” Which doesn’t make a ton of sense because Best disease causes my eyesight to get worse and worse over time. It’s a lot like age-related macular degeneration, but it’s genetic, and my vision could deteriorate at any time, not just when I’m 80.
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+20 +1
CRISPR may not cause hundreds of rogue mutations after all
A scientific journal has retracted a controversial paper, published last year, that suggested the gene-editing tool CRISPR was a genome wrecking ball. In the retracted study, researchers sought to use CRISPR in mice to correct a mutation that causes blindness. They successfully fixed the genetic error but reported that CRISPR inadvertently made more than a thousand other changes—potentially harmful ones—in the animals’ DNA.
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+9 +1
CRISPR successfully lowers cholesterol in mice
Biomedical engineers have used a CRISPR/Cas9 genetic engineering technique to turn off a gene that regulates cholesterol levels in adult mice, leading to reduced blood cholesterol levels and gene repression lasting for six months after a single treatment. This marks the first time researchers have delivered CRISPR/Cas9 repressors for targeted therapeutic gene silencing in adult animal models. The study appears in Nature Communications.
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+3 +1
A transplant of CRISPR-edited liver cells could replace lifelong injections for hemophilia B patients
A Salk Institute team transplanted liver cells into mouse models of hemophilia B, finding that the treatment restored their ability to form blood clots for a year. The hope is that this one-and-done treatment could replace the frequent injections of clotting factors that are currently used to treat the inherited blood disorder.
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+15 +1
CRISPR Could Eliminate Genetic Disease: UCSD Scientist
It's so small it can’t be seen with the naked eye, but research is showing that CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is bringing sight to the blind.
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+12 +1
CRISPR-edited rice plants increase grain yield by up to 31%
Scientists from China and the USA report the use of CRISPR/Cas9 to develop a variety of rice producing 25-31% more grain than traditional breeding methods.