In the coming adventure video game Sea of Solitude, the main character — a young woman named Kay — navigates a partly submerged city as she faces a multitude of red-eyed scaly creatures. None are as terrifying as her own personal demons. As the game progresses, Kay realizes the creatures she is encountering are humans who turned into monsters when they became too lonely. To save herself, she fights to overcome her own loneliness.

Johns Hopkins researchers have discovered that use of the synthetic psychedelic 5-methocy-N,-N-dimethyltryptamine (5-MeO-DMT) appears to be associated with unintended improvements in self-reported depression and anxiety when given in a ceremonial group setting. 5-MeO-DMT is a psychedelic that is found in the venom of Bufo Alvarius toads, in a variety of plants species, and can be produced synthetically.

Humor can help decrease negative emotional reactions in people vulnerable to depression, according to new research published in the journal Brain and Behavior. The findings offer preliminary evidence that humor could be an effective emotion regulation strategy.

The US Food and Drug Administration approved Janssen Pharmaceuticals Inc.'s esketamine on Tuesday for treatment-resistant depression; the drug is the chemical cousin of ketamine, the powerful anesthetic that has been used illegally as the club drug Special K. It will be sold as Spravato. More specifically, it's for patients who have tried at least two other medications without success, and it should be taken with an oral antidepressant.

Here we take a look at five celebrities who have been diagnosed with bipolar disorder and has never shied away from creating awareness on the mental health condition. #WorldBipolarDay #BipolarStrong #intlbipolar #InternationalBipolarFoundation #bipolar #bipolardisorder #mentalhealth #midplus #rehabilitation #depressiontreatment #stresstreatment #ludhiana #punjab

Today, young people are more likely to suffer from depression and self-harm than they were 10 years ago, even as substance abuse and anti-social behavior continue to fall, a new study says. Depression levels rose to nearly 15 percent among people born between the early 1990s to 2000, while self-harm rates increased to 14 percent, research published Thursday in the International Journal of Epidemiology shows.

The Food and Drug Administration on Tuesday approved esketamine, the first major depression treatment to hit the U.S. market in decades and a new option for patients who haven’t responded to existing therapies.

Physicians have been taught to look for signs of hopelessness, sadness and lack of motivation to help them diagnose depression. But anger as a depression symptom is less often noticed or addressed.

New research from QBI may explain why vitamin D is so important to brain plasticity, and how vitamin D deficiency leads to a range of cognitive disorders, including depression and schizophrenia. This paves way for new research that could lead to preventative strategies or better interventions for people with cognitive disorders associated with vitamin D deficiency. More than a billion people worldwide are affected by vitamin D deficiency. Moreover, there is a well-established link between vitamin D deficiency and impaired cognition.

According to the FDA, you may be able to.

Spending too much time on “social media” sites like Facebook is making people more than just miserable. It may also be making them depressed. A new study looked at 504 millennials who actively use Facebook, Twitter, Instagram, and/or Snapchat, individuals who met the criteria for a major depressive disorder scored higher on the “Social Media Addiction” scale.

The psychedelic drug psilocybin could help alleviate depression by causing people to have a less pessimistic outlook on life, according to preliminary research published in Frontiers in Psychology. Previous research has found that depression is associated with unrealistic negative predictions of future life events. Scientists from the Psychedelic Research Group at Imperial College London were interested in whether psilocybin — the main psychoactive compound in magic mushrooms — could reduce these pessimism biases.

You wander through life as if half-awake, time passing by. Activities you used to enjoy are now trite, exhausting, and empty of meaning. You feel alienated from others, who now seem far away, belonging to an inaccessible, alternate world where happiness is still possible. You are pushed further into the dark, hateful place inside yourself, where your thoughts– abusive, apathetic, and pessimistic– swirl relentlessly: I hate myself, it’s all pointless, I want to die. From where you are, there seems to be no hope, no relief, no escape. You are depressed.

A commonly used anesthetic drug could help people with severe depression. Preliminary research published in the International Journal of Neuropsychopharmacology suggests that propofol may trigger rapid, durable antidepressant effects. “Severe depression strikes millions of people each year, and up to one-third of these individuals do not respond to currently available treatments (medications, psychotherapy, brain stimulation),” said Brian James Mickey of the University of Utah, the corresponding author of the study.

To fight a rising tide of depression and suicide, psychiatrists need to do more than just fill patients up with pills writes James S Gordon, a psychiatrist

Although depression is one of the leading psychiatric disorders in Germany, its cause remains unclear. A recent study at the Max Planck Institute for Human Cognitive and Brain Sciences (MPI CBS) in Leipzig, Germany, and the Department of Psychiatry and Psychotherapy of the University Clinic in Leipzig found that those affected by depressive disorder have a larger hypothalamus compared to their healthy counterparts.

A huge rise in the number of people taking antidepressant drugs is potentially posing a threat to the environment, according to new research. An expert in the effects of human waste on marine life and an expert in ethical pharmacology, both at the University of Portsmouth, are calling for prescribers to be taught what happens when drugs in human waste enter the environment.

Psychology researchers in Ireland have shed new light on why volunteering is associated with reduced depressive symptoms.

By Emma Young. More research is needed into people who experience “high functioning after depression”.

Ph.D. candidates suffer from anxiety, depression, and suicidal ideation at astonishingly high rates.

New research suggests that exposure to childhood adversity is associated with reduced cognitive control and alterations in key brain networks. The findings, which appear in the journal Social Cognitive and Affective Neuroscience, could help explain the link between childhood adversity and depression.

A new age of bitcoin is about to begin, as users around the world will no longer need internet access to spend the cryptocurrency on everyday transactions. The startup Blockstream, which raised $101 million from Khosla Ventures and others, is now streaming the entire bitcoin blockchain from five satellites strategically positioned in orbit around Earth to reach all major landmasses.

FMT for manic depression? Maybe.

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Releasing the shoulds…

A Pennsylvania man says his emotional support alligator helps him deal with his depression. Joie Henney, 65, said his registered emotional support animal named Wally likes to snuggle and give hugs, despite being a 5-foot-long alligator. The York Haven man said he received approval from his doctor to use Wally as his emotional support animal after not wanting to go on medication for depression, he told Philly.com.

So, here are ten things I am grateful for in my mental health– fall edition.

Medication and talking therapies are key to treating depression but eating a range of nutritious foods can also play a role in boosting our mood.

by Apostle Gabriel Cross For those of you whom have grown tired in doing what is right and are battling with feelings of discouragement, anxiety, or torment. The Father says you are in a narrow pla…

More than 1700 people are estimated to have jumped off the Golden Gate Bridge since 1937. Kevin Hines attempted suicide at Golden Gate Bridge and survived. Now suicide prevention is his mission, including the creation of a Golden Gate Bridge suicide net.

Some people have a legitimate reason to feel depressed, but not me. I just woke up one day feeling sad and helpless for absolutely no reason.

On Monday, August 11, 2014, the world lost a great man. Robin Williams was found unresponsive in his home and it was suspected to be a suicide via asphyxiation.

You own a home, have a family, and are generally happy but have been feeling “off” lately. You work hard, you are feeling more tired than usual, and don’t know why. One day, you return from work and sit down to watch some television to unwind from your hard day. Your family hasn’t come home yet so you head to the kitchen to fix yourself a PB & J sandwich to tie yourself over until supper.

Last November, my father took his own life. I'm frequently aware of the fact that the depression which helped drive him to that dark fate lives on in my genes. That's a doozy of a legacy to inherit, but it's one that has not been wholly negative for me.