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+19 +1
CRISPR therapy may reverse autism mutation’s effects well past infancy
Injecting the gene-editing tool CRISPR into the brains of adolescent mice counteracts the effects of a mutation in a top autism gene. The finding suggests that mutations in this gene, SCN2A, may be treatable at any age.
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+25 +1
Geneticists retract study suggesting first CRISPR babies might die early
A study that raised questions over the future health of the world’s first gene-edited babies has been retracted because of key errors that undermined its conclusion.
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+14 +1
Researchers unlock potential to use CRISPR to alter the microbiome
Researchers at Western University have developed a new way to deliver the DNA-editing tool CRISPR-Cas9 into microorganisms in the lab, providing a way to efficiently launch a targeted attack on...
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+2 +1
CRISPR flies have been gene edited so they can eat poison
Scientists at the University of California, Berkeley have used the CRISPR gene-editing tool to give fruit flies an evolutionary advantage they’ve never had before. By making just three small changes to a single gene, the team gave the flies the ability to effectively eat poison and store it in their bodies, protecting themselves from predators in the process.
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+16 +1
New CRISPR Class Expands Genetic Engineering Toolbox
Biomedical engineers at Duke University have used a previously unexplored CRISPR technology to accurately regulate and edit genomes in human cells.
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+15 +1
Some cancer drugs miss their target. CRISPR could improve their aim
Method that generated drug leads may be flawed
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+12 +1
Could gene therapy be the solution to obesity and diabetes?
Researchers in South Korea the gene-editing technology CRISPR-Cas9 to inhibit the gene FABP4 in white adipose tissue. When they tried it in mice, the animals lost 20% of their body weight and showed reductions in inflammation and insulin resistance.
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+13 +1
Forget single genes: CRISPR now cuts and splices whole chromosomes
New ability gives biologists tool to rework bacterial genomes in many ways
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+4 +1
CRISPR enters its first human clinical trials
The gene editor will be used in lab dishes in cancer and blood disorder trials, and to directly edit a gene in human eyes in a blindness therapy test.
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+21 +1
Doctors altered a person's genes with CRISPR for the first time in the U.S. Here's what could be next.
Last week, a young woman with sickle cell anemia became the first person in the United States to have her cells altered with CRISPR gene editing technology. Here's what that means for the future treatment of genetic diseases.
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+21 +1
GM humans are possible, but do we really want them?
We are entering a new era as a species. For the first time, we are not only able to read our genetic code but also edit it. This will revolutionise our ability to treat disease and it will improve the lives of millions if not billions of people. But it means that, if we want to, we can now edit human embryos to “improve” the characteristics of our children. We will be able to create designer babies and these changes will be passed on to their descendants, which will change the human species forever.
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+15 +1
With its CRISPR revolution, China becomes a world leader in genome editing
For many people, CRISPR plus China equals the biophysicist He Jiankui, who infamously used the genome editor last year to alter the DNA of two human embryos that would become twin girls. Before his announcement, He was little-known within the country's CRISPR community, which has grown rapidly and is now challenging—and by some measures surpassing—the United States in its use of the powerful tool (see graphics below).
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+18 +1
First Human CRISPR Trial in the US Aims to Cure Inherited Blindness
Gene editing is advancing at a faster pace than most of us can keep up with. One significant recent announcement was gene editing tool CRISPR’s application to non-genetic diseases thanks to a new ability to edit single letters in RNA.
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+39 +1
Study will test CRISPR gene editing inside the body for first time
Patients are about to be enrolled in the first study to test a gene-editing technique known as CRISPR inside the body to try to cure an inherited form of blindness. People with the disease have normal eyes but lack a gene that converts light into signals to the brain that enable sight.
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+20 +1
CRISPR is less like molecular scissors and more like molecular malware
Last week I read an article about CRISPR, the latest tool scientists are using to edit DNA. It was a great piece – well researched, beautifully written, factually accurate. It covered some of the amazing projects scientist are working on using CRISPR, like bringing animals back from extinction and curing diseases.…
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+2 +1
Using CRISPR to resurrect the woolly mammoth
It really is worse than you think. We've gorged ourselves on fossil fuels, vacuumed up the Earth's forests and spewed toxic gases into the atmosphere for years on end. The planet is getting warmer, we're poisoning insect populations with reckless abandon and pulling fish out of the ocean at an alarming rate. The most recent prognosis for a biodiverse Earth is incredibly grim, with 1 million
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+26 +1
Scientists Reveal Unexpected Outcome of China's Rogue Human Gene Editing Trial
In 2018, the Chinese scientist He Jiankui, Ph.D., altered the DNA of two human embryos, which were born as two healthy twin girls named Lulu and Nana. Against the violent ethical uproar in the medical community, He defended his experiment by claiming that the genetic changes he made were benign — they were meant to promote HIV resistance — but research published Monday in Nature Medicine has revealed that he may have spoken too soon.
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+10 +1
CRISPR baby mutation significantly increases mortality
A genetic mutation that a Chinese scientist attempted to create in twin babies born last year, ostensibly to help them fend off HIV infection, is also associated with a 21% increase in mortality in later life, according to an analysis by University of California, Berkeley, scientists.
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+11 +1
A Deceptively Simple Tweak to CRISPR Makes It 50 Times More Accurate
CRISPR may be the premiere gene editing progeny poised to upend natural genomes and erase inherited diseases. But since its inception, one thing has always stood in the way: accuracy. Back in 2017, a contentious report using CRISPR found massive off-target edits in mice, in which the tool went rogue to snip away at innocent genes.
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+3 +1
CRISPR gene-editing creates wave of exotic model organisms
Joseph Parker has wanted to know what makes rove beetles tick since he was seven years old. The entomologist has spent decades collecting and observing the insects, some of which live among ants and feed on their larvae. But without tools for studying the genetic and brain mechanisms behind the beetles’ behaviour, Parker focused his PhD research on Drosophila fruit flies — an established model organism.
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