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  • exikon
    +2

    Be careful with the Tylenol. It's being metabolised by the liver which is busy doing that to all the ethanol. The problem is that a toxic metabolite is being produced that is normally "caught" by an antioxidant (glutathione). Unfortunately that is also used in large amounts during the detox of ethanol and ethanol inhibits the production of new glutathione. Very broadly spoken. I'm a bit fuzzy on the details though so there might be mistakes in that chain. The point is that tylenol and alcohol are not a good combo so if you can avoid it you should. Not to mention that you normally sleep for longer than the tylenol is actually active so it's doubtful you have any benefit from it.

    • idlethreat
      +2

      Thanks for the warning. I don't know enough about that to comment. Suffice it to say, all of the relevant bits are still working fine on this end, even though I seldom check out the owners manual.

      • exikon
        +1

        Generally speaking it wont be a problem if you pop a tylenol before going to bed after drinking. It strains the same degradation pathways as ethanol does though and as both have toxic metabolites that better get degraded further asap that's probably not a good idea. As long as your liver is not already damagd you should be fine but why risk it for the doubtful possibility that it might prevent a headache. As far as I'm concearned lots of water and a multivitamin pill are mostly what I use.

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