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New drug targets for lethal brain cancer discovered
More than 200 genes with novel and known roles in glioblastoma – the most aggressive type of brain cancer – offer promising new drug targets. Researchers from the Wellcome Sanger Institute, Addenbrooke’s Hospital and their collaborators engineered a new mouse model to show for the first time how a mutation in the well-known cancer gene, EGFR initiates glioblastoma, and works with a selection from more than 200 other genes to drive the cancer.