Red wine at a friend's parents party when I was 15. I knew about alcohol but I'd only ever had a couple of glasses at the most. Four large glasses later I was being exceedingly sick over the loo. Friend's mum came in with some bicarbonate of soda in water to drink. I knocked it back with relish, asked for, and got, another one then went to bed really rather early. In the morning I was famished, so cooked and ate a big greasy breakfast. I felt fine. No-one else did. :)

Damn, it just never occurred to me to see if the bicarb trick would work again!