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Do antidepressants work? If so, which antidepressants are most effective? These two questions have been posed again and again over the last few decades, but the answer has remained elusive. The latest answer to the question of which antidepressants are most effective and well-tolerated comes from a 2018 paper. Published in The Lancet, the paper reported the results of the largest meta-analysis conducted to date on the acceptability and efficacy of 21 antidepressant treatments