Working in an academic lab, it's a common knowledge that the higher the impact factor of the journal (think Nature and Cell), the less likely the results will be reproducible. Another question is whether it's because of some intrinsic differences between the labs and procedures or whether it's because some scientists haven't been exactly honest about their results and have cut corners to make that high impact publication. I find it completely unacceptable. Mostly, it's tax payers money being wasted with no benefit for the society. There hasn't been proper effort to tackle it though as it would probably require to move away from the current system of publish or perish, impact factors and the way academic work gets evaluated and funded.
Working in an academic lab, it's a common knowledge that the higher the impact factor of the journal (think Nature and Cell), the less likely the results will be reproducible. Another question is whether it's because of some intrinsic differences between the labs and procedures or whether it's because some scientists haven't been exactly honest about their results and have cut corners to make that high impact publication. I find it completely unacceptable. Mostly, it's tax payers money being wasted with no benefit for the society. There hasn't been proper effort to tackle it though as it would probably require to move away from the current system of publish or perish, impact factors and the way academic work gets evaluated and funded.