A brain signal for psychosis risk

Only one third of individuals identified as being at clinical high risk for psychosis actually convert to a psychotic disorder within a three-year follow-up period. This risk assessment is based on the presence of sub-threshold psychotic-like symptoms. Thus, clinical symptom criteria alone do not predict future psychosis risk with sufficient accuracy to justify aggressive early intervention, especially with medications such as antipsychotics that produce significant side effects.

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