Anthony Senerchia, whose struggle with the motor disease amyotrophic lateral sclerosis (ALS) was an early inspiration for the viral “ALS Ice Bucket Challenge,” died November 25 after a 14-year long battle with the disease, according to an online obituary. He was 46. Senerchia, from Pelham, N.Y., was diagnosed with the disease in 2003, shortly after marrying his wife Jeanette Hane. He was given only a few years to live, but he powered through the disease for the next 14 years, his obituary reads.

The Ice Bucket Challenge of two summers ago did more than deliver a chilly thrill to millions of people. The money it raised has led to an important breakthrough in ALS research. Scientists at the University of Massachusetts Medical School have discovered a new gene that's responsible for the disease. Genetic testing in over 1,000 ALS families showed 3 percent of patients had a variation of the gene that supplies neurons and repairs DNA.

Money raised from the Ice Bucket Challenge that went viral last year has significantly boosted research into ALS, scientists at Johns Hopkins say. They say it has helped them to understand more about a dysfunctional protein - TDP-43 - a mystery scientists have been studying for decades. ALS is a rare condition affecting the nervous system.

On April 20, 2009, a moment arrived that doctors had foretold for decades. Stephen Hawking, a scientist who overcame debilitating disease to become the world’s most renowned living physicist, was on the cusp of death. The University of Cambridge released grim prognoses. Hawking, diagnosed with amyotrophic lateral sclerosis (ALS) at the age of 21, was described as “very ill” and “undergoing tests” at the hospital.

Belgian photographer Bruno Brokken is in critical condition after having 396 gallons of water dropped on him from a firefighting plane at a height of only 22 feet near Girona, Spain. That's thousands of pounds of water.

Anthony Carbajal is living a life few young adults could fathom. The 26-year old suffering from ALS is sharing his heartbreaking story, and his thoughts on the Ice Bucket Challenge.

Bubbles takes the ALS Ice Bucket Challenge! Thanks to Julian for the ice and Ricky for loaning his piss bucket. ALS CAN FUCK OFF SO DONATE NOW!!

The ALS Ice Bucket Challenge has quickly gone from a fundraising campaign to a viral Internet sensation, raising $15.6 million so far for the ALS Association to research Lou Gehrig’s disease. Nominates Bill Gates, Lady Gaga, Cristiano Ronaldo, Justin Bieber, Jennifer Lopez, Mark Zuckerberg.