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PC Gaming Show Official description:

PC gaming is in a golden age With more powerful and affordable hardware than ever before, thousands of games available through Steam, Origin and other platforms, and millions of viewers regularly watching esports online. Now, for the first time, the PC platform will have its own event during E3, where the community will be able to celebrate this era with some of the biggest names in PC gaming and see the innovations that lie ahead. Hosted by Sean ‘Day[9]’ Plott, the PC Gaming Show will take place at the Belasco Theater in Los Angeles on Tuesday, June 16, 2015. In partnership with Twitch, the PC Gaming Show will be streamed live, and feature new game reveals, updates on beloved series, and perspectives from key PC developers.

Here are some of my favorites:

Auralnauts: Clever and hilarious mash-ups, and remixed media goodness.

AngryCentaurGaming: A great video game channel, featuring articulate, and detailed reviews and opinion (console and PC).

boogie2988: What can I say about Boogie... He's a great guy, who offers some incredibly insightful, and inspiring opinions on life, gaming, media, etc.

CaptainDisillusion: "In a world where the content of digital images and videos can no longer be taken at face value, an unlikely hero fights for the acceptance of truth. Captain Disillusion guides children of all ages through the maze of visual fakery to the open spaces of reality and peace of mind. Subscribe to get fun and detailed explanations of current "unbelievable" viral videos that fool the masses!" -The Official Description

CorridorDigital: If you're not familiar with these fellas, you'll definitely recognize some of their work. Indie filmmakers focused on actiony, effects heavy, game inspired content. They do some incredible (and incredibly entertaining) stuff.

DisneyShorts: Shockingly good Disney shorts.

Infinite Solutions: This channel is dead, but should still be remembered for offering the very best in technical "solutions". Definitely check their stuff out.

juliansmith87: A hilarious, and off-the-wall scetch comedy channel.

LinusTechTips: In terms of PC related youtube channels Linus and his pals set the standard IMO.

NewRetroWave: Here's a great channel to discover some fantastic music, in a genre that deserves more attention.

On Cinema: Because film criticism needs a bit more Tim Heidecker.

Pete Holmes: Pete's probably my favorite standup comic. His channel features more sketches than standup, and they're mostly all hilarious, and very clever.

Tested: Man Tested is wonderful for a number of reasons. Norman and Wil (and Adam Savage too) share their insightful opinions, reviews, and helpful information relating to geeky, techy, and just plain intere...

Those are some great suggestions. I wanted to add that Chris Stuckmann's reviews really are fantastic. I'm sure my opinion is heavily based on the fact that he and I seem to have near identical tastes, and opinions. Beyond that though, his reviews aren't excessively long, or annoyingly short. He's great about not including spoilers. Though he does give a brief plot synopsis for the movie, which some may want to avoid depending on how little you want to know about the plot of an anticipated film. Though it's never anything beyond what you'd find on the film's IMDb page. These days I like knowing as little about a movie as possible (just enough to gain my interest), but if I'm on the fence I'll check out Stuckmann's review, and know I'll likely feel the same way.

Every Frame a Painting is an absolutely rad channel as well. His stuff makes me feel smart, and dumb at the same time. It's a very synergistic combination!