Small-Molecule Probes: Bridging the gap between understanding and curing disease
Why do we have cures and medicines for some diseases but not others? Surprisingly, it is not because we cannot make the medicines; it is because we do not know enough about the diseases that need new medicines. To span the chasm between understanding the biology of a disease and successfully treating patients, we must foster collaborative efforts between biology and chemistry. The hope is that such cross-field cooperation will enable insights into disease biology by using chemical compounds that could lead to FDA-approved therapeutics.