The cost of a vital cancer drug has gone up 15-fold in four years after its new owner hiked prices on nine separate occasions. Lomustine has been used to treat brain tumours, lung cancer and Hodgkin’s lymphoma for more than 40 years but is now seen by some patients as too expensive. In 2013, production of the drug, which was previously called CeeNU, passed from pharma giant Bristol-Myers Squibb to a Miami-based startup called NextSource Biotechnology.

The retired firefighter, 53, needs Revlimid to stay healthy. Celgene Corp. has raised the price 88 percent over the past seven years. The drug doesn’t have substantial competition from a less expensive generic version, and probably won’t for another eight years. Celgene has worked hard to make sure of that.

With every toilet flush, we expose fish and other aquatic wildlife to the pharmaceuticals we're taking. By Reynard Loki.

You’re aware America is under siege, fighting an opioid crisis that has exploded into a public-health emergency. You’ve heard of OxyContin, the pain medication to which countless patients have become addicted. But do you know that the company that makes Oxy and reaps the billions of dollars in profits it generates is owned by one family? By Christopher Glazek.

Mike Moore made cigarette companies pay for the high cost of treating smokers. Here he comes again.

Probably one of the last things the pharma industry wants to talk about today is the cost of drugs. Or does it? Industry trade group PhRMA has launched new advertising meant to tackle the issue head-on. The national campaign, “Let’s Talk About Cost,” is a specific print, radio, digital and social effort, but that moniker will also now serve as the branded umbrella for all of PhRMA’s cost and value communications that have been going on for years.

Hospitals and pharmacies are required to toss expired drugs, no matter how expensive or vital. Meanwhile the FDA has long known that many remain safe and potent for years longer.

Cory Booker was once a drug industry ally. Now he’s refusing money from what he calls “folks who are profiting off the backs of the sick.” By Zaid Jilani.

Martin Shkreli, the pharmaceutical entrepreneur vilified as the "pharma bro" for raising the price of a life-saving drug by 5,000 percent, will go on trial on Monday for what U.S. prosecutors called a Ponzi-like scheme at his former hedge fund and a drug company he once ran.

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Penicillin once ushered in modern medicine. Now, shortages of the drug are creating new, antibiotic-resistant bacteria. By Keila Guimaraes.

Psychiatric drugs haven’t improved much in decades. So researchers are trying to develop better models of the brain to help them understand mental illness. By Meghana Keshavan. (Feb. 15, 2017)

How pharmacy benefit managers morphed from processors to predators. By David Dayen.

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A drug sold for years overseas to treat a rare form of muscular dystrophy was OKed Thursday by the FDA to be sold in the U.S., but it comes at a high price. The Wall Street Journal reports the now-FDA-approved deflazacort will be offered by Marathon Pharmaceuticals for $89,000 or so a year, up to 70 times its cost outside the U.S.; Marathon CFO Babar Ghias tells the Washington Post the net price will be $54,000 after rebates and discounts. Some who rely on it to treat Duchenne muscular dystrophy...

The new plan is tax cuts and deregulation. By Matthew Yglesias.

Mayor Ray Stephanson is ready to move forward with a civil lawsuit against Purdue Pharma, a drug manufacturer. Mayor Stephanson says the city has internal emails that show the company knowingly allowed OxyContin into the black market, and he claims the city will have to spend tens of millions of dollars to deal with the drug problem now plaguing Everett. Hil Kaman is the city's Public Health and Safety Director, and he's been investigating the problem.

As doctors and regulators restrict access to opioid treatments, many patients who genuinely need drugs to manage their pain say they are being left behind. By Bob Tedeschi.

At the recent 2017 Allied Social Sciences Association (ASSA) meeting in Chicago, Nobel Laureate Angus Deaton described the American healthcare system as “optimally designed for rent-seeking and very poorly designed to improve people’s health…” By Maureen Meehan.

Drugmakers have brought almost 450 orphan drugs to market and collected rich incentives by doing so. But nearly a third of the medicines aren’t new or were repurposed many times for financial gain. By Sarah Jane Tribble, Sydney Lupkin.