On the down-side, it will prove a curse to consumers seeking the lowest possible prices, and a potential death sentence to small e-commerce businesses, which don't have the software tools needed to deal with 50 sets of new tax regulations.

Does not surprise me. Gotta suck in as much money as they can without regard to how much people are already paying just for shipping.We are nothing but money pots to these people.

I know some guys who are independent sellers on Amazon. It remains to be seen if Amazon is going to collect sales tax for all transactions, or if the independent third-party sellers (using Amazon as a platform) will have to somehow collect and remit sales tax themselves.